Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 17/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.66 |
| ▸ | NCOR2 | Q9Y618 | 6/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241853 | 0.85 | USP2 (0.61) | USP2HDAC1HDAC3HDAC2HDAC10 | |
| SCHEMBL7694996 | 0.82 | USP2 (0.85) | USP2POLBMAPTTSHR | |
| SCHEMBL17009233 | 0.82 | USP2 (0.85) | USP2POLBMAPTTSHR | |
| SCHEMBL8241153 | 0.81 | HDAC3 (1.00) | HDAC1HDAC3HDAC2HDAC10HDAC6 | |
| SCHEMBL17009271 | 0.80 | USP2 (0.88) | USP2POLBMAPTTSHR | |
| SCHEMBL13438260 | 0.80 | USP2 (0.93) | USP2POLBMAPTTSHR | |
| SCHEMBL1938006 | 0.79 | HDAC3 (1.00) | HDAC1HDAC3HDAC2NCOR2HDAC4 | |
| SCHEMBL1938490 | 0.78 | HDAC3 (1.00) | HDAC1HDAC3HDAC2HDAC10HDAC6 | |
| SCHEMBL9784530 | 0.78 | USP2 (0.82) | USP2POLBMAPTTSHR | |
| SCHEMBL17009332 | 0.77 | USP2 (0.82) | USP2POLBMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |