SCHEMBL3242005

SCHEMBL3242005

Fc1ccccc1-c1ccc(NCCc2ccccn2)nc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.58
MKNK1 Q9BUB5 2/20 0.50
ALDH1A1 P00352 2/20 0.49
KDM4E B2RXH2 1/20 0.49
MEN1 O00255 1/20 0.49
POLB P06746 1/20 0.49
HPGD P15428 1/20 0.49
KMT2A Q03164 1/20 0.49
HSD17B10 Q99714 1/20 0.49
APP P05067 3/20 0.45
CDK9 P50750 1/20 0.44
HIF1A Q16665 1/20 0.44
HRH3 Q9Y5N1 1/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
LMNA P02545 2/20 0.42
TAAR1 Q96RJ0 1/20 0.42
ALOX15 P16050 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3245564 0.81 CYP1A2 (0.55) CYP1A2MKNK1ALDH1A1APPCDK9
SCHEMBL3244025 0.79 CYP1A2 (0.61) CYP1A2MKNK1ALDH1A1APPHRH3
SCHEMBL3243114 0.79 CYP1A2 (0.61) CYP1A2MKNK1ALDH1A1KDM4EMEN1
SCHEMBL5488816 0.76 KDM4E (0.46) CYP1A2ALDH1A1KDM4EMEN1POLB
SCHEMBL27513658 0.75 CYP1A2 (1.00) CYP1A2MKNK1ALDH1A1APPHRH3
SCHEMBL6677526 0.75 CYP1A2 (0.69) CYP1A2MKNK1ALDH1A1APPHRH3
SCHEMBL1108633 0.75 CYP1A2 (0.69) CYP1A2MKNK1ALDH1A1KDM4EMEN1
SCHEMBL3249134 0.74 HRH1 (0.42) CYP1A2HIF1AHRH3CHRNA7
SCHEMBL13763363 0.73 CYP1A2 (0.65) CYP1A2MKNK1ALDH1A1KDM4EPOLB
SCHEMBL3244438 0.72 CYP1A2 (0.52) CYP1A2MKNK1ALDH1A1APPCDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010057833-A1 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY BIOMARIN IGA, LTD. (BS) 2010-05-27 WO claimed
WO-2010057833-A1 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY BIOMARIN IGA, LTD. (BS) 2010-05-27 WO disclosed