Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 4/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108633 | 0.89 | CYP1A2 (0.69) | CYP1A2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL3244025 | 0.84 | CYP1A2 (0.61) | CYP1A2ALDH1A1NPC1RAB9AAPP | |
| SCHEMBL3242005 | 0.79 | CYP1A2 (0.58) | CYP1A2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL12994650 | 0.78 | NPC1 (0.68) | CYP1A2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL13763363 | 0.78 | CYP1A2 (0.65) | CYP1A2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL2940424 | 0.78 | MKNK1 (0.83) | MKNK1 | |
| SCHEMBL27513658 | 0.77 | CYP1A2 (1.00) | CYP1A2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6677526 | 0.77 | CYP1A2 (0.69) | CYP1A2ALDH1A1NPC1RAB9AAPP | |
| SCHEMBL3244438 | 0.77 | CYP1A2 (0.52) | CYP1A2ALDH1A1APPMKNK1HRH3 | |
| SCHEMBL13757443 | 0.77 | CYP1A2 (0.63) | CYP1A2ALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |