Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.49 |
| ▸ | GLS | O94925 | 10/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | EIF4E | P06730 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13645753 | 0.81 | HPGD (0.45) | ROCK2EIF4E | |
| SCHEMBL3242363 | 0.78 | ROCK1 (0.51) | ROCK1ROCK2GLSMAPK14MAPK1 | |
| SCHEMBL1114987 | 0.78 | ROCK2 (0.51) | ROCK1ROCK2GLSMAPK14MAPK1 | |
| SCHEMBL3409157 | 0.77 | MAPT (0.60) | ROCK1ROCK2GLSMAPK14MAPK1 | |
| SCHEMBL690748 | 0.77 | ROCK2 (0.52) | ROCK1ROCK2GLSMAPK14MAPK1 | |
| SCHEMBL31703630 | 0.75 | SCN10A (0.46) | ROCK1ROCK2SCN10AGLSMAPK1 | |
| SCHEMBL3608651 | 0.74 | ROCK1 (0.60) | ROCK1ROCK2GLSMAPK14MAPK1 | |
| SCHEMBL14256086 | 0.73 | MAPK14 (0.62) | ROCK1ROCK2GLSMAPK14ABCB1 | |
| SCHEMBL2212039 | 0.72 | ABCB1 (0.51) | ROCK1ROCK2GLSMAPK14MAPK1 | |
| SCHEMBL27931805 | 0.72 | ROCK2 (0.66) | ROCK1ROCK2GLSMAPK14ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099677-A1 | Compounds, Compositions and Methods Comprising Thiazole Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-04-22 | — | — | US | claimed |
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
| US-20100099677-A1 | Compounds, Compositions and Methods Comprising Thiazole Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-04-22 | — | — | US | disclosed |
| US-20100099677-A1 | Compounds, Compositions and Methods Comprising Thiazole Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-04-22 | — | — | US | disclosed |
| US-20100099677-A1 | Compounds, Compositions and Methods Comprising Thiazole Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-04-22 | — | — | US | disclosed |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-12-24 | — | — | US | disclosed |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-12-24 | — | — | US | disclosed |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | ROCK1 2801/4885ROCK2 3358/4885SCN10A 1158/4885 |
| US-20100099677-A1 | Compounds, Compositions and Methods Comprising Thiazole Derivatives | CFTR, PKD1, PKD2 | ROCK1 2497/4885ROCK2 2835/4885SCN10A 1413/4885 |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | CFTR, PKD1, PKD2 | ROCK1 2801/4885ROCK2 3358/4885SCN10A 1158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.