Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.56 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.56 |
| ▸ | TYR | P14679 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69021 | 0.88 | ESR1 (0.63) | ESR1ESR2PDCD1CD274TYR | |
| SCHEMBL30234474 | 0.88 | ESR1 (0.63) | ESR1ESR2PDCD1CD274TYR | |
| SCHEMBL21632759 | 0.81 | ESR1 (0.56) | ESR1ESR2PDCD1CD274TYR | |
| SCHEMBL28430447 | 0.80 | TYR (0.79) | ESR1ESR2PDCD1CD274TYR | |
| SCHEMBL6742674 | 0.79 | ESR1 (0.63) | ESR1ESR2TYRHSD17B10TTR | |
| SCHEMBL21632754 | 0.78 | ESR1 (0.52) | ESR1ESR2PDCD1CD274TYR | |
| SCHEMBL9590625 | 0.76 | TP53 (0.59) | HSD17B10LMNATP53HTTCYP3A4 | |
| SCHEMBL4293327 | 0.74 | ESR1 (0.62) | ESR1ESR2PDCD1CD274TYR | |
| SCHEMBL29390354 | 0.74 | ESR1 (0.62) | ESR1ESR2PDCD1CD274TYR | |
| SCHEMBL26946 | 0.73 | ESR1 (1.00) | ESR1ESR2PDCD1CD274TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010030787-A1 | ESTROGEN RECEPTOR LIGANDS | RADIUS HEALTH, INC. (US) | 2010-03-18 | — | — | WO | disclosed |