SCHEMBL32425027

SCHEMBL32425027

Clc1ncnc2cc[nH]c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 1.00
PDE4A P27815 1/20 0.42
PDE4B Q07343 1/20 0.42
PDE4C Q08493 1/20 0.42
PDE4D Q08499 1/20 0.42
EGFR P00533 13/20 0.40
ERBB2 P04626 13/20 0.40
ERBB3 P21860 13/20 0.40
ERBB4 Q15303 13/20 0.40
MKNK1 Q9BUB5 2/20 0.39
MKNK2 Q9HBH9 2/20 0.39
AXL P30530 1/20 0.39
IRAK4 Q9NWZ3 1/20 0.39
EIF4E P06730 1/20 0.36
MAPK1 P28482 1/20 0.35
AKT1 P31749 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8223 1.00 DYRK1A (1.00) DYRK1APDE4APDE4BPDE4CPDE4D
SCHEMBL23158613 0.78 DYRK1A (0.64) DYRK1AEGFRERBB2ERBB3ERBB4
SCHEMBL1056424 0.74 DYRK1A (0.59) DYRK1AEGFRERBB2ERBB3ERBB4
SCHEMBL13186164 0.74 DYRK1A (0.59) DYRK1AEGFRERBB2ERBB3ERBB4
SCHEMBL29702869 0.74 DYRK1A (0.59) DYRK1AEGFRMKNK1MKNK2IRAK4
SCHEMBL2078428 0.74 DYRK1A (0.59) DYRK1AEGFRERBB2ERBB3ERBB4
SCHEMBL397656 0.74 DYRK1A (0.59) DYRK1AEGFRMKNK1MKNK2IRAK4
SCHEMBL3386908 0.74 DYRK1A (0.59) DYRK1AEGFRERBB2ERBB3ERBB4
Hydrochloric Acid SCHEMBL3353317 0.72 DYRK1A (0.57) DYRK1AEGFRMKNK1MKNK2IRAK4
SCHEMBL20506184 0.71 DYRK1A (0.55) DYRK1AEGFRERBB2ERBB3ERBB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122036736-A Pyrrolo [2,3-d ] pyrimidine derivative, synthetic method and application 云南大学 2026-05-15 CN claimed
CN-122036736-A Pyrrolo [2,3-d ] pyrimidine derivative, synthetic method and application 云南大学 2026-05-15 CN disclosed