Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.50 |
| ▸ | MGLL | Q99685 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238410 | 0.88 | ROCK2 (0.64) | ROCK2POLBPDE3BPDE3ATP53 | |
| SCHEMBL3245430 | 0.81 | ROCK2 (0.62) | ROCK2MAPTPTGDR2RAB9AALDH1A1 | |
| SCHEMBL3245892 | 0.81 | ROCK2 (0.62) | ROCK2TP53MAPTNPC1RAB9A | |
| SCHEMBL3255236 | 0.80 | NPC1 (0.46) | ROCK2POLBMGLLNPC1RAB9A | |
| SCHEMBL5852207 | 0.78 | POLB (0.68) | ROCK2POLBTP53MAPTPTGDR2 | |
| SCHEMBL7295061 | 0.77 | ROCK2 (0.60) | ROCK2POLBPDE3BPDE3ATP53 | |
| SCHEMBL3248274 | 0.77 | ROCK2 (1.00) | ROCK2POLBMGLL | |
| SCHEMBL9128045 | 0.76 | ROCK2 (0.69) | ROCK2POLBPDE3BPDE3ATP53 | |
| SCHEMBL13390958 | 0.76 | ROCK2 (0.51) | ROCK2NPC1RAB9A | |
| SCHEMBL3786345 | 0.76 | KDM1A (0.60) | ROCK2POLBPDE3BPDE3ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |