Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 7/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | UQCRB | P14927 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254470 | 0.91 | PKM (0.53) | POLBPKMGAAARBRD4 | |
| SCHEMBL3248556 | 0.90 | MAPT (0.50) | POLBPKMKMT2AALDH1A1GAA | |
| SCHEMBL3242717 | 0.90 | ALDH1A1 (0.54) | POLBPKMKMT2AALDH1A1TSHR | |
| SCHEMBL3247955 | 0.89 | PKM (0.54) | POLBPKMKMT2AALDH1A1GAA | |
| SCHEMBL3244659 | 0.87 | POLB (0.57) | POLBPKMKMT2AALDH1A1TSHR | |
| SCHEMBL3249958 | 0.87 | MAPT (0.50) | POLBPKMKMT2AALDH1A1GAA | |
| SCHEMBL3249236 | 0.85 | BRD4 (0.60) | POLBBRD4MAPTPDE3A | |
| SCHEMBL3251158 | 0.85 | BRAF (0.44) | POLBPKMKMT2AALDH1A1TSHR | |
| SCHEMBL3248608 | 0.85 | POLB (0.46) | POLBPKMKMT2AALDH1A1GAA | |
| SCHEMBL4155342 | 0.84 | SIRT2 (0.41) | POLBPKMKMT2AHSD17B2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |