Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.55 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.54 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.51 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243500 | 0.81 | MAP3K5 (0.60) | SCN9AKCNH2SCN5AMAP3K5AURKA | |
| SCHEMBL16158635 | 0.78 | EGFR (0.58) | SCN9ATNNI3KEGFRBTK | |
| SCHEMBL14384401 | 0.78 | MTNR1A (0.62) | P2RX3POLB | |
| SCHEMBL3245173 | 0.77 | SCN9A (0.85) | SCN9AKCNH2SCN5A | |
| SCHEMBL28400978 | 0.77 | EGFR (0.75) | KCNH2EGFRBTKJAK2 | |
| SCHEMBL30423295 | 0.77 | EGFR (0.75) | KCNH2EGFRBTKJAK2 | |
| SCHEMBL3245142 | 0.76 | SCN9A (0.73) | SCN9AKCNH2SCN5A | |
| SCHEMBL2219871 | 0.75 | POLB (0.72) | MAP3K5AURKAAURKBJAK2POLB | |
| SCHEMBL11656245 | 0.75 | KMT2A (0.69) | POLB | |
| SCHEMBL3247903 | 0.74 | SCN9A (0.69) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |