Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247378 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2NTMT1CYP2D6HTTL3MBTL1 | |
| SCHEMBL25247324 | 0.90 | CHRM3 (0.46) | SMN1; SMN2NTMT1CYP2D6HTTL3MBTL1 | |
| SCHEMBL25595757 | 0.83 | CHRM4 (0.40) | SMN1; SMN2NTMT1ATM | |
| SCHEMBL28790450 | 0.82 | DPP4 (0.40) | SMN1; SMN2NTMT1ALDH1A1 | |
| SCHEMBL28673365 | 0.81 | NTMT1 (0.45) | SMN1; SMN2NTMT1CYP2D6CYP3A4ALDH1A1 | |
| SCHEMBL29033122 | 0.81 | CYP3A4 (0.50) | SMN1; SMN2NTMT1CYP2D6CYP3A4ALDH1A1 | |
| SCHEMBL29033156 | 0.81 | BCHE (0.45) | SMN1; SMN2NTMT1MEN1KMT2AALDH1A1 | |
| SCHEMBL28527261 | 0.80 | NTMT1 (0.46) | SMN1; SMN2NTMT1CYP2D6CYP3A4 | |
| SCHEMBL23089331 | 0.80 | CHRM3 (0.46) | SMN1; SMN2MEN1KMT2AATMALDH1A1 | |
| SCHEMBL29160750 | 0.80 | DPP4 (0.41) | SMN1; SMN2NTMT1L3MBTL1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2182809-A1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | Helicon Therapeutics, Inc. (US) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009029632-A1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | HELICON THERAPEUTICS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |