Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 4/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244356 | 1.00 | BTK (0.40) | BTKKAT6AKAT5JAK1JAK2 | |
| SCHEMBL4173768 | 0.86 | KAT6A (0.35) | BTKKAT6AKAT5KAT8MAPK8 | |
| Butyric Acid SCHEMBL4173769 | 0.81 | KAT6A (0.38) | BTKKAT6AKAT5JAK1JAK2 | |
| Hydrochloric Acid SCHEMBL3250727 | 0.81 | CSNK2A2 (0.32) | BTK | |
| Hydrochloric Acid SCHEMBL3250722 | 0.81 | CSNK2A2 (0.32) | BTK | |
| SCHEMBL3242979 | 0.74 | KDM4E (0.45) | JAK1JAK2JAK3 | |
| SCHEMBL3242728 | 0.74 | KDM4E (0.45) | JAK1JAK2JAK3 | |
| SCHEMBL3242729 | 0.74 | KDM4E (0.45) | JAK1JAK2JAK3 | |
| SCHEMBL3254879 | 0.72 | PRKAG1 (0.40) | — | |
| SCHEMBL4159322 | 0.66 | CCR8 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |