Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244481 | 1.00 | MAPT (0.39) | MAPTLMNARECQLPOLBHSP90AA1 | |
| SCHEMBL3249941 | 0.86 | ALDH1A1 (0.44) | MAPTLMNAPOLBRAB9ACYP1A2 | |
| SCHEMBL3249936 | 0.86 | ALDH1A1 (0.44) | MAPTLMNAPOLBRAB9ACYP1A2 | |
| SCHEMBL4165294 | 0.83 | APEX1 (0.39) | MAPTLMNARECQLPOLBHSP90AA1 | |
| SCHEMBL3245050 | 0.82 | PARP1 (0.44) | CYP1A2HPGDALDH1A1HSD17B10KMT2A | |
| SCHEMBL4715257 | 0.79 | MAPT (0.43) | MAPTLMNARECQLPOLBHSP90AA1 | |
| SCHEMBL3248408 | 0.79 | KDM4E (0.42) | MAPTLMNARAB9ACYP1A2HPGD | |
| SCHEMBL3245536 | 0.79 | MAPT (0.39) | MAPTLMNARECQLPOLBHSP90AA1 | |
| SCHEMBL3251484 | 0.78 | HSD17B10 (0.42) | POLBCYP1A2HPGDCYP2C19ALDH1A1 | |
| SCHEMBL3244728 | 0.78 | KDM4E (0.41) | LMNAPOLBRAB9ACYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |