Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.38 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | USP5 | P45974 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245050 | 0.85 | PARP1 (0.44) | KDM4ECYP1A2HSD17B10PARP1ALDH1A1 | |
| SCHEMBL3249741 | 0.85 | ALDH1A1 (0.48) | KDM4ECYP1A2HSD17B10PARP1ALDH1A1 | |
| SCHEMBL3249304 | 0.82 | NR4A2 (0.48) | KDM4ECYP1A2HSD17B10PARP1CSNK2A2 | |
| SCHEMBL3248408 | 0.82 | KDM4E (0.42) | KDM4ECYP1A2HSD17B10PARP1ALDH1A1 | |
| SCHEMBL3255989 | 0.82 | PARP1 (0.47) | KDM4ECYP1A2HSD17B10PARP1ALDH1A1 | |
| SCHEMBL3249100 | 0.82 | HNF4A (0.44) | KDM4ECYP1A2HSD17B10PARP1ALDH1A1 | |
| SCHEMBL3247782 | 0.82 | KDM4E (0.54) | KDM4ECYP1A2HSD17B10PARP1ALDH1A1 | |
| SCHEMBL3251105 | 0.81 | BRD4 (0.62) | KDM4ECYP1A2ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3245579 | 0.81 | KDM4E (0.44) | KDM4EPARP1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4159922 | 0.81 | HPGD (0.41) | KDM4EPARP1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |