Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250653 | 0.92 | POLB (0.57) | POLBPKMBRAFHSD17B10KDM4E | |
| SCHEMBL3254470 | 0.89 | PKM (0.53) | POLBPKMBRAFPDE3AMAPT | |
| SCHEMBL3248608 | 0.88 | POLB (0.46) | POLBPKMBRAFPDE3AMAPT | |
| SCHEMBL3248975 | 0.88 | POLB (0.49) | POLBPKMBRAFHSD17B10KMT2A | |
| SCHEMBL3247955 | 0.87 | PKM (0.54) | POLBPKMBRAFHSD17B10KDM4E | |
| SCHEMBL3248967 | 0.86 | PKM (0.47) | POLBPKMHSD17B10KDM4EUSP2 | |
| SCHEMBL3251084 | 0.86 | MAPT (0.50) | POLBPKMBRAFHSD17B10KDM4E | |
| SCHEMBL3249991 | 0.86 | BRD4 (0.50) | POLBPKMPDE3AMAPTTP53 | |
| SCHEMBL3251303 | 0.86 | PDE3A (0.45) | POLBPKMBRAFHSD17B10KDM4E | |
| SCHEMBL3251476 | 0.85 | BRD4 (0.48) | POLBMAPTTP53KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |