Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3248780 | 0.94 | BRD4 (0.58) | BRD4MAPTGAAPKMWDR5 | |
| SCHEMBL3247955 | 0.91 | PKM (0.54) | BRD4PDE3AMAPTGAAPOLB | |
| SCHEMBL3254470 | 0.91 | PKM (0.53) | BRD4PDE3AMAPTGAAPOLB | |
| SCHEMBL3250653 | 0.90 | POLB (0.57) | BRD4PDE3AMAPTGAAPOLB | |
| SCHEMBL3251303 | 0.90 | PDE3A (0.45) | BRD4PDE3AMAPTGAAPOLB | |
| SCHEMBL3251084 | 0.90 | MAPT (0.50) | PDE3AMAPTGAAPOLBPKM | |
| SCHEMBL3242717 | 0.89 | ALDH1A1 (0.54) | BRD4MAPTGAAPOLBPKM | |
| SCHEMBL3248608 | 0.88 | POLB (0.46) | BRD4PDE3AMAPTGAAPOLB | |
| SCHEMBL3249048 | 0.87 | POLB (0.54) | BRD4MAPTGAAPOLBTDP1 | |
| SCHEMBL3251641 | 0.87 | BRD4 (0.61) | BRD4MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |