Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.74 |
| ▸ | MYLK | Q15746 | 3/20 | 0.74 |
| ▸ | TP53 | P04637 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | GMNN | O75496 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.72 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30610303 | 0.94 | USP2 (0.66) | CYP3A4MAPK1CYP2D6MYLKTP53 | |
| SCHEMBL654111 | 0.94 | USP2 (0.66) | CYP3A4MAPK1CYP2D6MYLKTP53 | |
| SCHEMBL2869228 | 0.85 | CYP3A4 (1.00) | CYP3A4MAPK1CYP2D6MYLKTP53 | |
| SCHEMBL2959421 | 0.85 | POLB (0.57) | CYP3A4MAPK1CYP2D6MYLKTP53 | |
| Hydrochloric Acid SCHEMBL29370764 | 0.84 | MAPK1 (1.00) | CYP3A4MAPK1CYP2D6MYLKTP53 | |
| Hydrochloric Acid SCHEMBL1848494 | 0.84 | MAPK1 (1.00) | CYP3A4MAPK1CYP2D6MYLKTP53 | |
| SCHEMBL4555453 | 0.83 | TSHR (0.78) | CYP3A4MAPK1MEN1KMT2ACYP2C9 | |
| SCHEMBL31684034 | 0.83 | TSHR (0.78) | CYP3A4MAPK1MEN1KMT2ACYP2C9 | |
| Hydrochloric Acid SCHEMBL1986979 | 0.83 | CYP3A4 (0.95) | CYP3A4MAPK1CYP2D6MYLKTP53 | |
| SCHEMBL3245089 | 0.83 | CYP3A4 (0.60) | CYP3A4MAPK1CYP2D6MYLKTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586577-B2 | Diazepane acetamide derivatives as selective 11B-HSD1 inhibitors | MERCK PATENT GMBH (DE) | 2013-11-19 | — | — | US | disclosed |
| US-20120283247-A1 | DIAZEPANE ACETAMIDE DERIVATIVES AS SELECTIVE 11B-HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2012-11-08 | — | — | US | disclosed |
| US-8242107-B2 | Diazepane-acetamide derivatives as selective 11β-HSD1 inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-08-14 | — | — | US | disclosed |
| EP-2078001-B8 | DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11 -HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-12-15 | — | — | EP | disclosed |
| EP-2078001-B1 | DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11 -HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-05-12 | — | — | EP | disclosed |
| US-20100069365-A1 | Diazepane-acetamide derivatives as selective 11B-HSD1 inhibitors | MERCK PATENT GMBH (DE) | 2010-03-18 | — | — | US | disclosed |
| EP-2078001-A1 | DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11 -HSD1 INHIBITORS | Merk Patent Gmbh (DE) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008052638-A1 | DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS | MERK PATENT GMBH (DE) | 2008-05-08 | — | — | WO | disclosed |
| EP-1918285-A1 | Diazepane-acetamide derivatives as selective 11beta-HSD1 inhibitors | Merck Sante (FR) | 2008-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069365-A1 | Diazepane-acetamide derivatives as selective 11B-HSD1 inhibitors | HSD11B1, HSD11B2, HSD17B1 | CYP3A4 285/4885MAPK1 519/4885CYP2D6 357/4885 |
| US-20120283247-A1 | DIAZEPANE ACETAMIDE DERIVATIVES AS SELECTIVE 11B-HSD1 INHIBITORS | HSD11B1, HSD11B2, HSD17B1 | CYP3A4 336/4885MAPK1 476/4885CYP2D6 400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.