Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238582 | 0.90 | GPR119 (0.48) | GPR119THRBSMN1; SMN2MAPTLMNA | |
| SCHEMBL3241101 | 0.86 | GPR119 (0.59) | GPR119THRBMAPTLMNAPOLB | |
| SCHEMBL3118835 | 0.83 | GPR119 (0.51) | GPR119 | |
| SCHEMBL3243152 | 0.81 | GPR119 (0.49) | GPR119THRBSMN1; SMN2MAPTLMNA | |
| SCHEMBL3246751 | 0.78 | GPR119 (0.47) | GPR119THRBSMN1; SMN2 | |
| SCHEMBL3232246 | 0.78 | SMN1; SMN2 (0.35) | SMN1; SMN2KDM4E | |
| SCHEMBL20522288 | 0.76 | GPR119 (0.51) | GPR119THRBMAPTPOLBKDM4E | |
| SCHEMBL5655120 | 0.76 | MAPT (0.46) | GPR119THRBMAPTPOLBKDM4E | |
| SCHEMBL3122663 | 0.75 | GPR119 (0.48) | GPR119 | |
| SCHEMBL3126148 | 0.74 | GPR119 (0.53) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001166-A1 | THIAZOLE DERIVATIVES AS GPR 119 MODULATORS | PROSIDION LIMITED (GB) | 2010-01-07 | — | — | WO | claimed |