Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238582 | 0.89 | GPR119 (0.48) | GPR119SMN1; SMN2THRB | |
| SCHEMBL3245221 | 0.87 | GPR119 (0.47) | GPR119SMN1; SMN2CLK2CLK3GSK3B | |
| SCHEMBL3130130 | 0.82 | GPR119 (0.53) | GPR119 | |
| SCHEMBL3247060 | 0.82 | F9 (0.42) | SMN1; SMN2F9DYRK1A | |
| SCHEMBL3251903 | 0.81 | LMNA (0.47) | GPR119SMN1; SMN2 | |
| SCHEMBL3244500 | 0.78 | GPR119 (0.46) | GPR119SMN1; SMN2THRB | |
| SCHEMBL3241101 | 0.76 | GPR119 (0.59) | GPR119THRB | |
| SCHEMBL3118783 | 0.74 | GPR119 (0.51) | GPR119 | |
| SCHEMBL3126976 | 0.73 | GPR119 (0.48) | GPR119 | |
| SCHEMBL3119362 | 0.71 | GPR119 (0.49) | GPR119SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001166-A1 | THIAZOLE DERIVATIVES AS GPR 119 MODULATORS | PROSIDION LIMITED (GB) | 2010-01-07 | — | — | WO | claimed |