Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.42 |
| ▸ | BID | P55957 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.41 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6287955 | 0.98 | LIPG (0.53) | LIPGNR1H2NR1H3CYSLTR2CYSLTR1 | |
| SCHEMBL6409297 | 0.96 | LIPG (0.50) | LIPGNR1H2NR1H3CYSLTR2CYSLTR1 | |
| SCHEMBL8903099 | 0.89 | LIPG (0.45) | LIPGNR1H2NR1H3CYSLTR2CYSLTR1 | |
| SCHEMBL5573340 | 0.84 | LIPG (0.39) | LIPGNR1H2NR1H3CYSLTR2CYSLTR1 | |
| SCHEMBL1583827 | 0.83 | CYP4F2 (0.33) | LIPG | |
| SCHEMBL9332722 | 0.80 | LIPG (0.53) | LIPGNR1H2NR1H3CYSLTR2CYSLTR1 | |
| SCHEMBL9810035 | 0.80 | LIPG (0.53) | LIPGNR1H2NR1H3CYSLTR2CYSLTR1 | |
| SCHEMBL11094055 | 0.79 | BID (0.42) | LIPGBIDMCL1BCL2L1BAK1 | |
| SCHEMBL18496530 | 0.78 | LIPG (0.69) | LIPGNR1H2NR1H3CYSLTR2CYSLTR1 | |
| SCHEMBL6679764 | 0.78 | LIPG (0.69) | LIPGNR1H2NR1H3CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225205-B1 | Carbon black reacted with diazonium salts and products | CABOT CORP (US) | 2010-10-06 | — | — | EP | disclosed |
| EP-1942156-B1 | Carbon black reacted with diazonium salts and products | CABOT CORP (US) | 2010-04-14 | — | — | EP | disclosed |
| EP-1942156-A1 | Carbon black reacted with diazonium salts and products | Cabot Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| US-7294185-B2 | In absence of exterior applies electrical current; wear resistance | CABOT CORPORATION (US) | 2007-11-13 | — | — | US | disclosed |
| EP-0799281-B2 | CARBON BLACK REACTED WITH DIAZONIUM SALTS AND PRODUCTS | CABOT CORP (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050034629-A1 | In absence of exterior applies electrical current; wear resistance | BELMONT JAMES A (US) | 2005-02-17 | — | — | US | disclosed |
| US-6740151-B2 | IN THE ABSENCE OF AN EXTERNALLY APPLIED ELECTRIC CURRENT SUFFICIENT TO REDUCE THE DIAZONIUM SALT AND ATTACH AN ORGANIC GROUP; IMPROVED ABRASION RESISTANCE. | CABOT CORPORATION | 2004-05-25 | — | — | US | disclosed |
| US-20030095914-A1 | In the absence of an externally applied electric current sufficient to reduce the diazonium salt and attach an organic group; improved abrasion resistance. | BELMONT JAMES A (US) | 2003-05-22 | — | — | US | disclosed |
| US-6494946-B1 | PROCESSES FOR PREPARING A CARBON BLACK PRODUCT HAVING AN ORGANIC GROUP ATTACHED TO THE CARBON BLACK. IN ONE PROCESS AT LEAST ONE DIAZONIUM SALT REACTS WITH A CARBON BLACK IN THE ABSENCE OF AN EXTERNALLY APPLIED ELECTRIC CURRENT SUFFICIENT | CABOT CORPORATION | 2002-12-17 | — | — | US | disclosed |
| EP-0799281-B1 | CARBON BLACK REACTED WITH DIAZONIUM SALTS AND PRODUCTS | CABOT CORP (US) | 2002-07-24 | — | — | EP | disclosed |
| EP-1225205-A2 | Carbon black reacted with diazonium salts and products | CABOT CORPORATION (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6042643-A | AS PIGMENT TO COLOR PLASTICS, PAPER, TEXTILE, RUBBER, AQUEOUS INKS | CABOT CORPORATION (US) | 2000-03-28 | — | — | US | disclosed |
| US-5900029-A | COLORING FIBER OR TEXTILE | CABOT CORPORATION (US) | 1999-05-04 | — | — | US | disclosed |
| US-5851280-A | Reaction of carbon black with diazonium salts, resultant carbon black products and their uses | CABOT CORPORATION (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0799281-A1 | CARBON BLACK REACTED WITH DIAZONIUM SALTS AND PRODUCTS | CABOT CORPORATION (US) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996018688-A1 | CARBON BLACK REACTED WITH DIAZONIUM SALTS AND PRODUCTS | CABOT CORPORATION (US) | 1996-06-20 | — | — | WO | disclosed |