Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250548 | 0.91 | HPGD (0.56) | HSD17B10HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3245348 | 0.90 | HSD17B10 (0.69) | HSD17B10HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3247194 | 0.89 | HPGD (0.48) | HSD17B10HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3251817 | 0.88 | CRHBP (0.49) | HSD17B10HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3242740 | 0.85 | HPGD (0.48) | HSD17B10HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3248232 | 0.83 | HSD17B10 (0.47) | HSD17B10HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3252256 | 0.80 | MAPT (0.44) | HSD17B10HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3247632 | 0.80 | KMT2A (0.58) | HSD17B10HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3254539 | 0.79 | MAPT (0.48) | HSD17B10HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL3248331 | 0.79 | KDM4E (0.60) | HSD17B10HPGDKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |