Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246214 | 0.91 | HSD17B10 (0.55) | CRHBPCRHR2HSD17B10HPGDALDH1A1 | |
| SCHEMBL3254539 | 0.91 | MAPT (0.48) | CRHBPCRHR2HSD17B10HPGDALDH1A1 | |
| SCHEMBL3250657 | 0.90 | CRHBP (0.49) | CRHBPCRHR2HSD17B10HPGDALDH1A1 | |
| SCHEMBL3244949 | 0.88 | HSD17B10 (0.55) | CRHBPCRHR2HSD17B10HPGDALDH1A1 | |
| SCHEMBL3247541 | 0.85 | MEN1 (0.44) | CRHBPCRHR2HSD17B10HPGDALDH1A1 | |
| SCHEMBL3249025 | 0.85 | MAPT (0.52) | CRHBPCRHR2HSD17B10HPGDALDH1A1 | |
| SCHEMBL3255439 | 0.83 | HSD17B10 (0.54) | HSD17B10HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL3255494 | 0.82 | MAPT (0.44) | CRHBPCRHR2HSD17B10HPGDALDH1A1 | |
| SCHEMBL13928146 | 0.82 | HSD17B10 (0.53) | HSD17B10HPGDALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL3250275 | 0.81 | HSD17B10 (0.52) | HSD17B10HPGDALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |