Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.51 |
| ▸ | HTR7 | P34969 | 6/20 | 0.51 |
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | HTR1A | P08908 | 5/20 | 0.51 |
| ▸ | HRH1 | P35367 | 5/20 | 0.51 |
| ▸ | HTR2B | P41595 | 5/20 | 0.51 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5534030 | 0.84 | HTR7 (0.43) | DRD2HTR7DRD3HTR1AHRH1 | |
| SCHEMBL5535345 | 0.84 | CARM1 (0.48) | DRD2HTR7DRD3ACACBPRMT5 | |
| SCHEMBL10231923 | 0.83 | HTR7 (0.42) | DRD2HTR7DRD3HTR1AHRH1 | |
| SCHEMBL3245091 | 0.82 | SLC6A4 (0.52) | DRD2HTR7DRD3HTR1AHRH1 | |
| SCHEMBL652976 | 0.82 | HTR7 (0.60) | DRD2HTR7DRD3HTR1AHRH1 | |
| SCHEMBL3245036 | 0.81 | DRD2 (0.44) | DRD2HTR7DRD3 | |
| SCHEMBL13678422 | 0.81 | TMEM97 (0.49) | DRD2HTR7DRD3MEN1KMT2A | |
| SCHEMBL10231918 | 0.80 | ABCB1 (0.45) | — | |
| SCHEMBL5023878 | 0.79 | CARM1 (0.48) | DRD2HTR7DRD3PRMT5WDR77 | |
| SCHEMBL5541021 | 0.79 | HTR7 (0.43) | DRD2HTR7DRD3HTR1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227803-B1 | COMPOUNDS FOR INHIBITING IAPP-ASSOCIATED AMYLOID DEPOSITS | BELLUS HEALTH INTERNATIONAL LTD (CH) | 2010-05-05 | — | — | EP | claimed |
| US-6562836-B1 | Islet amyloid polypeptide (IAPP) is known to be capable of forming fibrils which are deposited in the pancreas of patients wtih type II diabetes | QUEEN'S UNIVERSITY OF KINGSTON (CA) | 2003-05-13 | — | — | US | claimed |