Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.50 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182326 | 0.89 | TYMS (1.00) | TYMSLMNACYP3A4NFKB1BLM | |
| Ammonia Solution, Strong SCHEMBL1777238 | 0.86 | TYMS (0.92) | TYMSLMNACYP3A4NFKB1BLM | |
| SCHEMBL10632880 | 0.86 | TYMS (0.92) | TYMSLMNACYP3A4NFKB1BLM | |
| SCHEMBL14058843 | 0.86 | TYMS (0.92) | TYMSLMNACYP3A4NFKB1BLM | |
| Ammonia Solution, Strong SCHEMBL1643223 | 0.86 | TYMS (0.92) | TYMSLMNACYP3A4NFKB1BLM | |
| Benzene SCHEMBL27280214 | 0.83 | LPAR3 (0.68) | TYMSLMNACYP3A4NFKB1BLM | |
| Water SCHEMBL8165218 | 0.83 | TYMS (0.86) | TYMSLMNACYP3A4NFKB1BLM | |
| Hydrochloric Acid SCHEMBL9453438 | 0.83 | TYMS (0.86) | TYMSLMNACYP3A4NFKB1BLM | |
| SCHEMBL20235 | 0.82 | TYMS (0.85) | TYMSLMNACYP3A4NFKB1BLM | |
| Hydrochloric Acid SCHEMBL9437863 | 0.80 | TYMS (0.80) | TYMSLMNACYP3A4NFKB1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2210886-B1 | PYRIMIDYL INDOLINE COMPOUND | DAIICHI SANKYO CO LTD (JP) | 2015-09-23 | — | — | EP | disclosed |
| US-8765771-B2 | Condensed pyridine or condensed pyrimidine derivative, and medicinal agent comprising same | KOWA CO., LTD. (JP) | 2014-07-01 | — | — | US | disclosed |
| EP-2586781-A1 | NOVEL CONDENSED PYRIDINE OR CONDENSED PYRIMIDINE DERIVATIVE, AND MEDICINAL AGENT COMPRISING SAME | KOWA CO. LTD. (JP) | 2013-05-01 | — | — | EP | disclosed |
| US-20130102621-A1 | NOVEL CONDENSED PYRIDINE OR CONDENSED PYRIMIDINE DERIVATIVE, AND MEDICINAL AGENT COMPRISING SAME | KOWA CO., LTD. (JP) | 2013-04-25 | — | — | US | disclosed |
| US-8232287-B2 | Pyrimidyl indoline compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-07-31 | — | — | US | disclosed |
| US-20100292259-A1 | PYRIMIDYL INDOLINE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-11-18 | — | — | US | disclosed |
| EP-2210886-A1 | PYRIMIDYL INDOLINE COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2010-07-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102621-A1 | NOVEL CONDENSED PYRIDINE OR CONDENSED PYRIMIDINE DERIVATIVE, AND MEDICINAL AGENT COMPRISING SAME | IAPP, GPR119, RNASE1 | TYMS 2113/4885LMNA 4338/4885CYP3A4 4525/4885 |
| US-20100292259-A1 | PYRIMIDYL INDOLINE COMPOUND | GPR119, SLC5A2, SLC5A1 | TYMS 56/4885LMNA 4476/4885CYP3A4 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.