Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.53 |
| ▸ | KIT | P10721 | 5/20 | 0.53 |
| ▸ | FLT1 | P17948 | 5/20 | 0.53 |
| ▸ | AURKA | O14965 | 4/20 | 0.53 |
| ▸ | BRAF | P15056 | 5/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2193891 | 0.86 | MTNR1A (0.47) | KDRPDGFRBKITFLT1AURKA | |
| SCHEMBL2192600 | 0.83 | KDR (0.54) | KDRPDGFRBKITFLT1AURKA | |
| SCHEMBL2193901 | 0.82 | BRAF (0.44) | KDRPDGFRBKITFLT1AURKA | |
| SCHEMBL3251950 | 0.81 | PPARG (0.48) | — | |
| SCHEMBL2192740 | 0.81 | BRAF (0.64) | KDRPDGFRBKITFLT1AURKA | |
| SCHEMBL2194127 | 0.80 | BRAF (0.56) | KDRPDGFRBKITFLT1AURKA | |
| SCHEMBL2196644 | 0.77 | KDR (0.47) | KDRPDGFRBKITFLT1AURKA | |
| SCHEMBL2194492 | 0.77 | SMN1; SMN2 (0.55) | KDRPDGFRBKITFLT1AURKA | |
| SCHEMBL5351075 | 0.74 | CHEK2 (0.48) | KDRBRAF | |
| SCHEMBL2858491 | 0.73 | KDR (0.75) | KDRPDGFRBKITFLT1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2181987-B9 | 2-Carbonylaminobenzothiazoles and their use for the prophylaxis and treatment of cancer | TAKEDA PHARMACEUTICAL (JP) | 2014-09-03 | — | — | EP | disclosed |
| EP-2181987-B1 | 2-Carbonylaminobenzothiazoles and their use for the prophylaxis and treatment of cancer | TAKEDA PHARMACEUTICAL (JP) | 2014-03-05 | — | — | EP | disclosed |
| US-8324395-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-12-04 | — | — | US | disclosed |
| EP-2181987-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-05 | — | — | EP | disclosed |