Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.55 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240482 | 0.88 | HRH3 (0.60) | HRH3ALDH1A1KDM4ESMN1; SMN2PRMT6 | |
| SCHEMBL11196105 | 0.78 | NCF1 (0.83) | NCF1NOS1HRH3HTTALDH1A1 | |
| SCHEMBL2463951 | 0.77 | NCF1 (0.66) | NCF1NOS1HRH3HTTALDH1A1 | |
| SCHEMBL3245500 | 0.77 | HRH3 (0.71) | NCF1NOS1HRH3ALDH1A1HPGD | |
| SCHEMBL3240187 | 0.76 | HRH3 (0.66) | NCF1HRH3ALDH1A1KDM4E | |
| SCHEMBL3242385 | 0.75 | HRH3 (0.68) | HRH3ALDH1A1KDM4E | |
| SCHEMBL10235392 | 0.74 | NCF1 (0.71) | NCF1NOS1HRH3HTTALDH1A1 | |
| SCHEMBL16704825 | 0.74 | NCF1 (0.60) | NCF1NOS1HRH3HTTALDH1A1 | |
| SCHEMBL3240100 | 0.73 | BCHE (0.60) | HRH3ALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL13959553 | 0.73 | NCF1 (0.60) | NCF1NOS1HRH3HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | NCF1 1244/4885NOS1 4427/4885HRH3 2578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.