Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | FAAH | O00519 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | GPR183 | P32249 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19002246 | 0.87 | HRH3 (0.55) | ATMSMN1; SMN2LMNAALDH1A1L3MBTL1 | |
| SCHEMBL14642155 | 0.86 | HRH3 (0.54) | ATMSMN1; SMN2LMNAALDH1A1L3MBTL1 | |
| SCHEMBL27760871 | 0.86 | LMNA (0.58) | ATMSMN1; SMN2LMNAALDH1A1L3MBTL1 | |
| SCHEMBL2841801 | 0.85 | ALDH1A1 (0.68) | SMN1; SMN2LMNAALDH1A1L3MBTL1FAAH | |
| SCHEMBL27880545 | 0.85 | ATM (0.68) | ATMSMN1; SMN2LMNAALDH1A1L3MBTL1 | |
| SCHEMBL15264421 | 0.83 | LMNA (0.68) | ATMSMN1; SMN2LMNAALDH1A1L3MBTL1 | |
| SCHEMBL3239820 | 0.83 | HRH3 (0.78) | ATMSMN1; SMN2LMNAALDH1A1L3MBTL1 | |
| SCHEMBL19002261 | 0.83 | POLB (0.73) | SMN1; SMN2LMNAALDH1A1FAAHMAPT | |
| SCHEMBL9819832 | 0.83 | MEN1 (0.68) | ATMSMN1; SMN2LMNAALDH1A1L3MBTL1 | |
| SCHEMBL5537445 | 0.82 | ATM (0.64) | ATMSMN1; SMN2LMNAALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | ATM 2713/4885SMN1; SMN2 4546/4885LMNA 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.