Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNA2 | P51530 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245558 | 0.83 | CLEC4M (0.52) | DNA2CASP6CTDSP1PARP1FBP1 | |
| SCHEMBL3250627 | 0.79 | MAPT (0.46) | PARP1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL3249310 | 0.74 | DNA2 (0.67) | DNA2CASP6CTDSP1PARP1FBP1 | |
| SCHEMBL4739348 | 0.73 | CLEC4M (0.71) | DNA2CASP6CTDSP1MAPTNPC1 | |
| SCHEMBL3255981 | 0.73 | HIF1A (0.49) | MAPTMAPK1ALDH1A1KDM4ELMNA | |
| SCHEMBL4161648 | 0.72 | FBP1 (0.56) | DNA2CASP6CTDSP1PARP1FBP1 | |
| SCHEMBL3243057 | 0.72 | CHEK1 (0.37) | MAPK1L3MBTL1CLEC4MTYMSALDH1A1 | |
| SCHEMBL6199586 | 0.72 | PARP1 (0.50) | PARP1FBP1MAPTNPC1MAPK1 | |
| SCHEMBL3245727 | 0.72 | GABRA1 (0.50) | MAPTNPC1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL3251609 | 0.72 | PARP1 (0.44) | PARP1L3MBTL1CLEC4MTYMSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |