Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | MC5R | P33032 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469349 | 0.78 | PARP1 (0.38) | PARP1ALDH1A1TSHRLMNAMEN1 | |
| SCHEMBL28507911 | 0.73 | SSTR4 (0.40) | PARP1ALDH1A1TSHRLMNAMEN1 | |
| SCHEMBL925337 | 0.73 | AKT1 (0.56) | AKT1AKT2AKT3ALDH1A1DDB1 | |
| SCHEMBL30826881 | 0.71 | PARP1 (0.35) | PARP1TSHRLMNAMEN1KMT2A | |
| SCHEMBL30975054 | 0.71 | BTK (0.39) | PARP1AKT1 | |
| SCHEMBL30968430 | 0.70 | PARP1 (0.37) | PARP1ALDH1A1MC4RMC5RTSHR | |
| SCHEMBL29085915 | 0.70 | PARP1 (0.39) | PARP1ALDH1A1MC4RMC5RTSHR | |
| SCHEMBL29611977 | 0.70 | TSHR (0.36) | PARP1ALDH1A1TSHRLMNAMEN1 | |
| SCHEMBL2798262 | 0.70 | MAP4K4 (0.41) | PARP1MEN1KMT2A | |
| SCHEMBL14686612 | 0.70 | PARP1 (0.40) | PARP1ALDH1A1TSHRLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170863-A2 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009006567-A2 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-01-08 | — | — | WO | disclosed |