Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30975054 | 0.79 | BTK (0.39) | PARP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL3245906 | 0.78 | PARP1 (0.39) | PARP1TSHRLMNAALDH1A1MEN1 | |
| SCHEMBL29611977 | 0.77 | TSHR (0.36) | PARP1TSHRLMNAALDH1A1MAPT | |
| SCHEMBL30826881 | 0.77 | PARP1 (0.35) | PARP1TSHRLMNAMAPTMEN1 | |
| SCHEMBL28507911 | 0.76 | SSTR4 (0.40) | PARP1TSHRLMNAALDH1A1MEN1 | |
| SCHEMBL30826990 | 0.76 | PARP1 (0.37) | PARP1TSHRLMNAALDH1A1MAPT | |
| SCHEMBL31310721 | 0.74 | PARP1 (0.40) | PARP1TSHRLMNAALDH1A1POLB | |
| SCHEMBL30618068 | 0.74 | GPR119 (0.36) | PARP1TSHRLMNAMAPTMEN1 | |
| SCHEMBL2798262 | 0.73 | MAP4K4 (0.41) | PARP1MEN1KMT2AMAP4K4JAK3 | |
| SCHEMBL14686612 | 0.73 | PARP1 (0.40) | PARP1TSHRLMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130954-A1 | Serine/threonine protein kinase inhibitors; hyperproliferative disorder or inflammatory conditions; e.g. 4-(4-(2-amino-3-(p-chlorophenyl)-propionyl)-piperazin-1-yl)-quinazoline | ARRAY BIOPHARMA INC. | 2005-06-16 | — | — | US | disclosed |
| EP-1057867-B1 | RESIN DISPERSION, METHOD OF PREPARING THE SAME, RESIN-COATED METAL SHEET OBTAINED WITH THE SAME, AND PROCESS FOR PRODUCING LAMINATE | MITSUI CHEMICALS INC (JP) | 2005-04-20 | — | — | EP | disclosed |
| US-6833045-B1 | Solid particles of graft modified ethylene/ alpha -olefin copolymer dispersed in solvent; adhesive for packaging; coatings, primers | MITSUI CHEMICALS, INC. (JP) | 2004-12-21 | — | — | US | disclosed |
| EP-0924223-B1 | Catalyst component, catalyst and process for ethylenically unsaturated monomer polymerization | MITSUI CHEMICALS INC (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-6579935-B1 | Ethylene-alpha-olefin polymer grafted with an acrylic acid monomer; metallocene; impact resistance at low temperatures, stiffness, fracture toughness (tensile toughness) | MITSUI CHEMICALS, INC. (JP) | 2003-06-17 | — | — | US | disclosed |
| US-6444603-B1 | CATALYST COMPONENT OBTAINED BY REACTING COMPOUND COMPRISING METAL OF GROUP 13 OF PERIODIC TABLE, COMPOUND CAPABLE OF BEING BONDED TO TWO OR MORE OF GROUP 13 METAL, COMPOUND CAPABLE OF FORMING IONIZING IONIC COMPOUND WITH GROUP 13 COMPOUND | MITSUI CHEMICALS, INC. (JP) | 2002-09-03 | — | — | US | disclosed |
| US-6194114-B1 | BINDER RESIN, COLORANT, AND RELEASING AGENT COMPRISING AN ETHYLENE-AROMATIC VINYL COMPOUND RANDOM COPOLYMER HAVING NO C-NMR PEAK DUE TO AROMATIC VINYL-TO-AROMATIC VINYL BLOCK MADE WITH A METALLOCENE CATALYST; OFFSET RESISTANCE | MITSUI CHEMICALS, INC. (JP) | 2001-02-27 | — | — | US | disclosed |
| EP-1057867-A1 | RESIN DISPERSION, METHOD OF PREPARING THE SAME, RESIN-COATED METAL SHEET OBTAINED WITH THE SAME, AND PROCESS FOR PRODUCING LAMINATE | Mitsui Chemicals, Inc. (JP) | 2000-12-06 | — | — | EP | disclosed |
| US-6133490-A | WAX OF COPOLYMER OF ETHYLENE WITH AN AROMATIC VINYL COMPOUND. | MITSUI CHEMICALS INC. (JP) | 2000-10-17 | — | — | US | disclosed |
| EP-0924223-A2 | Catalyst component, catalyst and process for ethylenically unsaturated monomer polymerization | Mitsui Chemicals, Inc. (JP) | 1999-06-23 | — | — | EP | disclosed |
| EP-0896983-A1 | PIGMENT DISPERSANT FOR AROMATIC POLYMERS | Mitsui Chemicals, Inc. (JP) | 1999-02-17 | — | — | EP | disclosed |
| EP-0638594-B1 | Chlorinated ethylene/alpha-olefin copolymer rubber and composition containing the same | MITSUI CHEMICALS INC (JP) | 1998-12-02 | — | — | EP | disclosed |
| EP-0870801-A1 | ALPHA-OLEFIN/AROMATIC VINYL COPOLYMER COMPOSITION AND MOLDINGS THEREOF | Mitsui Chemicals, Inc. (JP) | 1998-10-14 | — | — | EP | disclosed |
| EP-0869146-A1 | ETHYLENE COPOLYMER COMPOSITION AND MOLDINGS | Mitsui Chemicals, Inc. (JP) | 1998-10-07 | — | — | EP | disclosed |
| US-5470919-A | Seals with ozone resistance, heat aging resistance, oil resistance and weatherproofing | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1995-11-28 | — | — | US | disclosed |
| EP-0638594-A1 | Chlorinated ethylene/alpha-olefin copolymer rubber and composition containing the same | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130954-A1 | Serine/threonine protein kinase inhibitors; hyperproliferative disorder or inflammatory conditions; e.g. 4-(4-(2-amino-3-(p-chlorophenyl)-propionyl)-piperazin-1-yl)-quinazoline | MTOR, CDK2, CLK2 | PARP1 1733/4885HPGDS 1387/4885TSHR 2389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.