Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243014 | 0.92 | PARP1 (0.45) | PARP1GAAGFERMAPTRAB9A | |
| SCHEMBL3251023 | 0.89 | CDC25A (0.43) | PARP1PDE5AGAAMAPTNPC1 | |
| SCHEMBL3251225 | 0.86 | CSNK2A1 (0.42) | PARP1GAAROCK2PIM1GSK3B | |
| SCHEMBL3251324 | 0.86 | BAZ2A (0.42) | PARP1 | |
| SCHEMBL3252051 | 0.85 | PARP1 (0.41) | PARP1GAAMAPTNPC1RAB9A | |
| SCHEMBL3249392 | 0.85 | PARP1 (0.46) | PARP1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3251009 | 0.85 | PARP1 (0.47) | PARP1BRD4MAPTNPC1SMN1; SMN2 | |
| SCHEMBL3254517 | 0.85 | HDAC3 (0.43) | PARP1 | |
| SCHEMBL3253872 | 0.85 | PARP1 (0.41) | PARP1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3250692 | 0.84 | HPGD (0.34) | PARP1GSK3BNPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |