Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252380 | 0.85 | CSF1R (0.43) | HPGDALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL3252260 | 0.85 | JMJD6 (0.36) | HPGDALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL3244562 | 0.85 | CCNC (0.38) | HPGDALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL3253850 | 0.84 | SCN9A (0.38) | HPGDALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL3252802 | 0.84 | GABRA1 (0.43) | HPGDALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL3246159 | 0.84 | PARP1 (0.47) | ALDH1A1HSD17B10NPC1PARP1TSHR | |
| SCHEMBL3249865 | 0.83 | KDM4E (0.40) | HPGDALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL3243014 | 0.83 | PARP1 (0.45) | ALDH1A1MEN1KMT2AL3MBTL1PARP1 | |
| SCHEMBL3252050 | 0.83 | GAA (0.40) | HPGDALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL3243023 | 0.83 | PIM1 (0.41) | GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |