Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL585671 | 0.81 | HTR5A (0.37) | PARP10CYP11B2CYP11B1 | |
| SCHEMBL3240383 | 0.75 | NISCH (0.33) | ESR2NISCHCYP11B2CYP11B1CA12 | |
| SCHEMBL1991616 | 0.73 | HTR5A (0.37) | PARP10CYP11B2CYP11B1 | |
| SCHEMBL3244951 | 0.71 | KCNH2 (0.42) | CYP11B2CYP11B1CYP17A1CYP3A4HRH3 | |
| SCHEMBL3128454 | 0.70 | KCNH2 (0.44) | NISCHCYP11B2CYP11B1CYP17A1CYP3A4 | |
| SCHEMBL198702 | 0.70 | TAAR1 (0.68) | CHRNB4CHRNA3TAAR1ESR2NISCH | |
| SCHEMBL3116016 | 0.68 | CHRNB4 (0.47) | CHRNB4CHRNA3TAAR1ESR2NISCH | |
| SCHEMBL9288568 | 0.68 | PARP10 (0.51) | PARP10PARP11TAAR1ESR2CYP11B2 | |
| SCHEMBL18554743 | 0.68 | ASIC3 (0.58) | PARP10PARP11 | |
| SCHEMBL16605626 | 0.67 | TAAR1 (0.65) | CHRNB4CHRNA3TAAR1ESR2NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |