Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3001166 | 0.92 | PKM (0.64) | THRBALDH1A1SMN1; SMN2KMT2AHTT | |
| SCHEMBL3004259 | 0.88 | PKM (0.62) | THRBALDH1A1SMN1; SMN2KMT2AHTT | |
| SCHEMBL3126934 | 0.83 | ALDH1A1 (0.59) | THRBALDH1A1SMN1; SMN2KMT2AHTT | |
| SCHEMBL3243338 | 0.82 | ALDH1A1 (0.67) | THRBALDH1A1SMN1; SMN2KMT2AHTT | |
| SCHEMBL3005609 | 0.81 | PKM (0.62) | THRBALDH1A1SMN1; SMN2KMT2AHTT | |
| SCHEMBL3002824 | 0.80 | ALDH1A1 (0.64) | THRBALDH1A1SMN1; SMN2KMT2AHTT | |
| SCHEMBL3247603 | 0.79 | PKM (0.59) | THRBALDH1A1SMN1; SMN2KMT2AHTT | |
| SCHEMBL3006633 | 0.78 | ALDH1A1 (0.62) | THRBALDH1A1SMN1; SMN2KMT2AHTT | |
| SCHEMBL3005234 | 0.78 | ALDH1A1 (0.66) | THRBALDH1A1SMN1; SMN2KMT2AHTT | |
| SCHEMBL2990880 | 0.77 | ALDH1A1 (0.67) | THRBALDH1A1SMN1; SMN2KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |