Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
| ▸ | PPARD | Q03181 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.46 |
| ▸ | KDM5A | P29375 | 2/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3590904 | 0.95 | FFAR1 (0.52) | FFAR1PPARDTP53L3MBTL1TSHR | |
| SCHEMBL30301824 | 0.95 | FFAR1 (0.52) | FFAR1PPARDTP53L3MBTL1TSHR | |
| SCHEMBL7845908 | 0.88 | FFAR1 (0.62) | FFAR1PPARD | |
| SCHEMBL7847075 | 0.88 | FFAR1 (0.62) | FFAR1PPARD | |
| SCHEMBL1470461 | 0.88 | FFAR1 (0.62) | FFAR1PPARD | |
| SCHEMBL2993635 | 0.83 | KDM4C (0.49) | TSHRHPGDBLMKDM4CKDM5A | |
| SCHEMBL7038866 | 0.83 | HAO1 (0.53) | TSHRBLMKDM4CKDM5AKDM5B | |
| SCHEMBL1568052 | 0.82 | BLM (0.51) | TSHRBLMKDM4CKDM5AKDM5B | |
| SCHEMBL830267 | 0.82 | SIGMAR1 (0.49) | — | |
| SCHEMBL1725811 | 0.81 | BLM (0.50) | TSHRBLMKDM4CKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2189443-B1 | TRICYCLIC AMIDE COMPOUND | RES FOUND ITSUU LAB (JP) | 2013-10-23 | — | — | EP | disclosed |
| US-8232300-B2 | Tricyclic amide compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2012-07-31 | — | — | US | disclosed |
| EP-2189440-A1 | TRICYCLIC AMINE COMPOUND | Research Foundation Itsuu Laboratory (JP) | 2010-05-26 | — | — | EP | disclosed |
| EP-2189443-A1 | TRICYCLIC AMIDE COMPOUND | Research Foundation Itsuu Laboratory (JP) | 2010-05-26 | — | — | EP | disclosed |