Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.50 |
| ▸ | KDM5A | P29375 | 2/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30301824 | 1.00 | FFAR1 (0.52) | FFAR1TSHRBLMHPGDKDM4C | |
| SCHEMBL3246802 | 0.95 | FFAR1 (0.51) | FFAR1TSHRBLMHPGDKDM4C | |
| SCHEMBL7847075 | 0.90 | FFAR1 (0.62) | FFAR1PPARD | |
| SCHEMBL7845908 | 0.90 | FFAR1 (0.62) | FFAR1PPARD | |
| SCHEMBL1470461 | 0.90 | FFAR1 (0.62) | FFAR1PPARD | |
| SCHEMBL2993635 | 0.88 | KDM4C (0.49) | TSHRBLMHPGDKDM4CKDM5A | |
| SCHEMBL7038866 | 0.87 | HAO1 (0.53) | TSHRBLMKDM4CKDM5AKDM5B | |
| SCHEMBL1568052 | 0.87 | BLM (0.51) | TSHRBLMKDM4CKDM5AKDM5B | |
| SCHEMBL1725811 | 0.85 | BLM (0.50) | TSHRBLMKDM4CKDM5AKDM5B | |
| SCHEMBL10584761 | 0.85 | TSHR (0.50) | TSHRBLMHPGDKDM4CKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58029721-A | — | — | None | — | — | JP | disclosed |
| JP-58015938-A | — | — | None | — | — | JP | disclosed |
| JP-57209235-A | — | — | None | — | — | JP | disclosed |
| US-12404265-B2 | Substituted pyridine derivatives as SARM1 inhibitors | NURA BIO, INC. (US) | 2025-09-02 | — | — | US | disclosed |
| US-11970481-B1 | Substituted pyridine derivatives as SARM1 inhibitors | NURA BIO, INC. (US) | 2024-04-30 | — | — | US | disclosed |
| US-20240116901-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. | 2024-04-11 | — | — | US | disclosed |
| US-20230339913-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. | 2023-10-26 | — | — | US | disclosed |
| US-20230339913-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. | 2023-10-26 | — | — | US | disclosed |
| EP-4192828-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | Nura Bio, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| CN-115820100-A | Flame-retardant coating containing polyurethane acrylate and preparation method thereof | 山东奔腾漆业股份有限公司 | 2023-03-21 | — | — | CN | disclosed |
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |
| EP-0737189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-10-16 | — | — | EP | disclosed |
| WO-1995018118-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1995-07-06 | — | — | WO | disclosed |
| US-5194437-A | Substituted with oxygen containing heterocycle, central nervous system disorders, neuroendocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-03-16 | — | — | US | disclosed |
| US-4443603-A | PROTEOLYTIC ENZYME INHIBITORS | KOWA COMPANY LIMITED (JP) | 1984-04-17 | — | — | US | disclosed |
| JP-S5829721-A | TETRAHYDRONAPHTHALENE DERIVATIVE AND ITS PREPARATION | SUMITOMO CHEM CO LTD | 1983-02-22 | — | — | JP | disclosed |
| JP-S5815938-A | OBTAINING METHOD OF OPTICALLY ACTIVE TETRAHYDRONAPHTHYLACETIC ACID DERIVATIVE | SUMITOMO CHEM CO LTD | 1983-01-29 | — | — | JP | disclosed |
| EP-0067561-A2 | Piperazine derivatives and processes for producing them | KOWA COMPANY, LTD. (JP) | 1982-12-22 | — | — | EP | disclosed |
| JP-S57209235-A | TETRAHYDRONAPHTHALENE DERIVATIVE AND ITS PREPARATION | SUMITOMO CHEM CO LTD | 1982-12-22 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12404265-B2 | Substituted pyridine derivatives as SARM1 inhibitors | SARM1, SARNP, ADRM1 | FFAR1 4246/4885TSHR 4223/4885BLM 3424/4885 |
| US-11970481-B1 | Substituted pyridine derivatives as SARM1 inhibitors | SARM1, SARNP, ADRM1 | FFAR1 4246/4885TSHR 4223/4885BLM 3424/4885 |
| US-20230339913-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | SARM1, SARNP, ADRM1 | FFAR1 4246/4885TSHR 4223/4885BLM 3424/4885 |
| US-20240116901-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | SARM1, SARNP, ADRM1 | FFAR1 4246/4885TSHR 4223/4885BLM 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.