Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 8/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254277 | 0.88 | KCNH2 (0.48) | MTNR1BMTNR1AMAPTALDH1A1HTT | |
| SCHEMBL1147392 | 0.87 | MTNR1B (0.54) | MTNR1BMTNR1AMAPTALDH1A1HTT | |
| SCHEMBL3252295 | 0.87 | CYP2C9 (0.44) | MTNR1BMTNR1AMAPTALDH1A1KMT2A | |
| SCHEMBL3256206 | 0.81 | MTNR1B (0.43) | MTNR1BMTNR1AMAPTALDH1A1HTT | |
| SCHEMBL3251533 | 0.77 | KCNH2 (0.49) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL3250106 | 0.75 | KCNH2 (0.47) | MTNR1BMTNR1AMAPTALDH1A1LMNA | |
| SCHEMBL1147923 | 0.75 | KCNH2 (0.54) | MTNR1BMTNR1AMAPTALDH1A1HTT | |
| SCHEMBL1147514 | 0.74 | MTNR1B (0.60) | MTNR1BMTNR1AALDH1A1 | |
| SCHEMBL1147517 | 0.74 | MTNR1B (0.60) | MTNR1BMTNR1AALDH1A1 | |
| SCHEMBL1147515 | 0.74 | MTNR1B (0.60) | MTNR1BMTNR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001478-B1 | CYCLOHEXYL OR PIPERIDINYL CARBOXAMIDE ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-06-02 | — | — | EP | claimed |