Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 8/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252106 | 0.89 | KCNH2 (0.46) | MTNR1BMTNR1ANPC1RAB9AALDH1A1 | |
| SCHEMBL1148001 | 0.88 | MTNR1B (0.51) | MTNR1BMTNR1ANPC1RAB9AALDH1A1 | |
| SCHEMBL3252295 | 0.86 | CYP2C9 (0.44) | MTNR1BMTNR1AALDH1A1KMT2AMAPT | |
| SCHEMBL3247289 | 0.81 | MTNR1B (0.46) | MTNR1BMTNR1ANPC1RAB9AALDH1A1 | |
| SCHEMBL3244059 | 0.78 | KCNH2 (0.40) | NPC1RAB9AALDH1A1LMNAKCNH2 | |
| SCHEMBL1147875 | 0.77 | KCNH2 (0.47) | MTNR1BMTNR1AKCNH2MAOAMAOB | |
| SCHEMBL3250106 | 0.75 | KCNH2 (0.47) | MTNR1BMTNR1AALDH1A1LMNAKCNH2 | |
| SCHEMBL1147668 | 0.74 | TRPV1 (0.55) | MTNR1BMTNR1A | |
| SCHEMBL3256183 | 0.72 | MAOA (0.46) | MTNR1BMTNR1AALDH1A1LMNAKCNH2 | |
| SCHEMBL3251532 | 0.72 | MAOA (0.46) | ALDH1A1LMNAKCNH2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001478-B1 | CYCLOHEXYL OR PIPERIDINYL CARBOXAMIDE ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-06-02 | — | — | EP | claimed |