⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL569888 | 0.79 | DGAT1 (0.31) | — | |
| SCHEMBL2785917 | 0.79 | DGAT1 (0.31) | — | |
| SCHEMBL136090 | 0.77 | HPGD (0.31) | — | |
| SCHEMBL5421441 | 0.77 | HPGD (0.31) | — | |
| SCHEMBL6519441 | 0.69 | ALDH1A1 (0.30) | — | |
| SCHEMBL15011734 | 0.67 | — | — | |
| SCHEMBL3388958 | 0.67 | — | — | |
| SCHEMBL1975008 | 0.66 | DGAT1 (0.30) | — | |
| SCHEMBL6504809 | 0.65 | CHRM2 (0.31) | — | |
| SCHEMBL8984073 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9551018-B2 | Process for the preparation of optically active chiral amines | LONZA AG (CH) | 2017-01-24 | — | — | US | claimed |
| US-20150284752-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE CHIRAL AMINES | LONZA AG (CH) | 2015-10-08 | — | — | US | claimed |
| EP-2202318-A1 | Process for the preparation of optically active chiral amines | Lonza AG (CH) | 2010-06-30 | — | — | EP | claimed |
| EP-1987152-B1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE CHIRAL AMINES | LONZA AG (CH) | 2010-05-26 | — | — | EP | claimed |
| US-20090246837-A1 | Process for The Preparation of Optically Active Chiral Amines | LONZA AG (CH) | 2009-10-01 | — | — | US | claimed |
| EP-1987152-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE CHIRAL AMINES | Lonza AG (CH) | 2008-11-05 | — | — | EP | claimed |
| WO-2007093372-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE CHIRAL AMINES | LONZA AG (CH) | 2007-08-23 | — | — | WO | claimed |
| US-11434192-B2 | Process and intermediates | NOVARTIS AG (CH) | 2022-09-06 | — | — | US | disclosed |
| EP-3558930-B1 | NEW PROCESS FOR EARLY SACUBITRIL INTERMEDIATES | NOVARTIS AG (CH) | 2021-05-26 | — | — | EP | disclosed |
| US-10774036-B2 | Process for early sacubitril intermediates | NOVARTIS AG (CH) | 2020-09-15 | — | — | US | disclosed |
| EP-3386955-B1 | INTERMEDIATES FOR THE PREPARATION OF SACUBITRIL AND THEIR PREPARATION | NOVARTIS AG (CH) | 2020-08-05 | — | — | EP | disclosed |
| US-20190308927-A1 | PROCESS AND INTERMEDIATES | NOVARTIS PHARMA AG (CH) | 2019-10-10 | — | — | US | disclosed |
| US-10377697-B2 | Process and intermediates | NOVARTIS AG (CH) | 2019-08-13 | — | — | US | disclosed |
| US-9074228-B2 | Process for the preparation of optically active chiral amines | LONZA AG (CH) | 2015-07-07 | — | — | US | disclosed |
| EP-2202317-A1 | Process for the preparation of optically active chiral amines | Lonza AG (CH) | 2010-06-30 | — | — | EP | disclosed |
| EP-2202318-A1 | Process for the preparation of optically active chiral amines | Lonza AG (CH) | 2010-06-30 | — | — | EP | disclosed |
| EP-1987152-B1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE CHIRAL AMINES | LONZA AG (CH) | 2010-05-26 | — | — | EP | disclosed |
| US-20090246837-A1 | Process for The Preparation of Optically Active Chiral Amines | LONZA AG (CH) | 2009-10-01 | — | — | US | disclosed |
| EP-1987152-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE CHIRAL AMINES | Lonza AG (CH) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093372-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE CHIRAL AMINES | LONZA AG (CH) | 2007-08-23 | — | — | WO | disclosed |