Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255565 | 0.93 | MEP1B (0.55) | TSHRMEP1BALDH1A1LMNAPOLB | |
| SCHEMBL3253721 | 0.92 | TSHR (0.48) | TSHRMEP1BALDH1A1POLBMAPT | |
| SCHEMBL3251190 | 0.87 | ALDH1A1 (0.46) | TSHRALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL3249160 | 0.87 | ALDH1A1 (0.53) | TSHRMEP1BALDH1A1LMNAPOLB | |
| SCHEMBL3253246 | 0.87 | MEP1B (0.48) | TSHRMEP1BALDH1A1LMNAMAPT | |
| SCHEMBL3247755 | 0.87 | MAPK1 (0.59) | TSHRMEP1BALDH1A1LMNAMAPT | |
| SCHEMBL3253380 | 0.85 | MAPT (0.52) | TSHRALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL3251138 | 0.85 | GAA (0.47) | TSHRALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL3255473 | 0.84 | ALDH1A1 (0.47) | TSHRMEP1BALDH1A1LMNAPOLB | |
| SCHEMBL3255588 | 0.84 | TSHR (0.46) | TSHRMEP1BALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776347-B1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI AVENTIS (FR) | 2010-05-26 | — | — | EP | disclosed |