Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | OGG1 | O15527 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10634934 | 0.84 | NOTUM (0.42) | SLC6A12NOTUMUSP2LMNAALOX15 | |
| SCHEMBL3240425 | 0.84 | SLC6A12 (0.46) | SLC6A12NOTUMACKR3ALDH1A1MAPK1 | |
| Formic Acid SCHEMBL10640837 | 0.81 | NOTUM (0.40) | SLC6A12NOTUMUSP2LMNAALOX15 | |
| SCHEMBL7503531 | 0.78 | HTR2A (0.39) | MEN1KMT2AACKR3ALDH1A1 | |
| SCHEMBL606330 | 0.78 | MEN1 (0.47) | NOTUMHRH4MEN1KMT2AALDH1A1 | |
| SCHEMBL606329 | 0.78 | MEN1 (0.47) | NOTUMHRH4MEN1KMT2AALDH1A1 | |
| SCHEMBL10634910 | 0.74 | KMT2A (0.47) | NOTUMUSP2LMNAALOX15HRH4 | |
| SCHEMBL21381592 | 0.74 | CPS1 (0.44) | MEN1KMT2AACKR3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10634903 | 0.73 | KMT2A (0.46) | NOTUMUSP2LMNAALOX15HRH4 | |
| SCHEMBL4983350 | 0.72 | HSD11B1 (0.55) | MEN1KMT2AACKR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183245-A2 | DUAL MODULATORS OF 5-HT2A AND D3 RECEPTORS | F. Hoffmann-Roche AG (CH) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009013212-A2 | DUAL MODULATORS OF 5-HT2A AND D3 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | WO | disclosed |