Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 1/20 | 0.52 |
| ▸ | PNMT | P11086 | 7/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026913 | 0.80 | ALDH1A1 (0.59) | MELKPNMTADRA2AADRA2BADRA2C | |
| SCHEMBL29589725 | 0.80 | ALDH1A1 (0.59) | MELKPNMTADRA2AADRA2BADRA2C | |
| SCHEMBL9561102 | 0.80 | ALDH1A1 (0.63) | — | |
| Trifluoroacetic Acid SCHEMBL1077606 | 0.79 | MELK (0.51) | MELKPNMT | |
| SCHEMBL29728413 | 0.79 | PNMT (0.53) | MELKPNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL15671006 | 0.79 | ALDH1A1 (0.58) | MELKPNMTADRA2AADRA2BADRA2C | |
| SCHEMBL3248558 | 0.79 | MELK (0.56) | MELKPNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1033504 | 0.79 | PNMT (0.53) | MELKPNMTADRA2AADRA2BADRA2C | |
| Trifluoroacetic Acid SCHEMBL31335937 | 0.78 | MELK (0.44) | MELKPNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL17748278 | 0.78 | PNMT (0.51) | MELKPNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227803-B1 | COMPOUNDS FOR INHIBITING IAPP-ASSOCIATED AMYLOID DEPOSITS | BELLUS HEALTH INTERNATIONAL LTD (CH) | 2010-05-05 | — | — | EP | claimed |
| US-6562836-B1 | Islet amyloid polypeptide (IAPP) is known to be capable of forming fibrils which are deposited in the pancreas of patients wtih type II diabetes | QUEEN'S UNIVERSITY OF KINGSTON (CA) | 2003-05-13 | — | — | US | claimed |
| US-7393875-B2 | Reducing islet amyloid polypeptide (IAPP) associated deposit; type II diabetes | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2008-07-01 | — | — | US | disclosed |