Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11117895 | 0.79 | KCNH2 (0.46) | KCNH2CYP19A1TDP1L3MBTL1MIF | |
| SCHEMBL2359176 | 0.78 | KCNH2 (0.44) | KCNH2TDP1L3MBTL1KMT2ANOS2 | |
| SCHEMBL426455 | 0.76 | KCNH2 (0.50) | KCNH2CYP19A1GABRA2GABRB2GPR84 | |
| SCHEMBL22616936 | 0.76 | KCNH2 (0.46) | KCNH2CYP19A1GABRA2GABRB2TDP1 | |
| SCHEMBL2364044 | 0.75 | MAPT (0.43) | KCNH2TDP1L3MBTL1MIFCYP2C9 | |
| SCHEMBL12539240 | 0.75 | KCNH2 (0.53) | KCNH2CYP19A1GABRA2GABRB2GPR84 | |
| SCHEMBL2364312 | 0.73 | KCNH2 (0.40) | KCNH2CYP19A1TDP1L3MBTL1MIF | |
| SCHEMBL791579 | 0.72 | KCNH2 (0.46) | KCNH2CYP19A1GABRA2GABRB2GPR84 | |
| SCHEMBL10830973 | 0.71 | KCNH2 (0.44) | KCNH2CYP19A1TDP1L3MBTL1MIF | |
| SCHEMBL4301655 | 0.70 | KCNH2 (0.53) | KCNH2CYP19A1TDP1L3MBTL1MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001220-A1 | NEW 1,2,4-TRIAZINE DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF | MUTABILIS SA (FR) | 2010-01-07 | — | — | WO | disclosed |
| EP-2141164-A1 | New 1,2,4-triazine derivatives and biological applications thereof | Mutabilis (FR) | 2010-01-06 | — | — | EP | disclosed |