Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003171 | 0.98 | KCNH2 (0.56) | KCNH2TDP1L3MBTL1CYP19A1ADRB3 | |
| SCHEMBL16178953 | 0.94 | KCNH2 (0.46) | KCNH2PDPK1TLR8 | |
| SCHEMBL24799116 | 0.81 | NOS2 (0.38) | KCNH2 | |
| SCHEMBL24258924 | 0.80 | KCNH2 (0.35) | KCNH2 | |
| SCHEMBL899234 | 0.79 | KCNH2 (0.55) | KCNH2TDP1L3MBTL1PDPK1TLR8 | |
| SCHEMBL11561943 | 0.79 | KCNH2 (0.55) | KCNH2TDP1L3MBTL1CYP19A1PDPK1 | |
| SCHEMBL27667823 | 0.79 | KCNH2 (0.42) | KCNH2L3MBTL1CNR2TLR8 | |
| SCHEMBL715269 | 0.78 | — | — | |
| SCHEMBL3248683 | 0.78 | KCNH2 (0.53) | KCNH2PDPK1TLR8 | |
| SCHEMBL22298878 | 0.78 | KCNH2 (0.58) | KCNH2TDP1L3MBTL1CYP19A1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114770-B1 | COMPOUNDS WITH DINITROGEN CONTAINING HETEROCYCLIC NUCLEUS, THEIR PROCESS OF PREPARATION AND MEDICINES ACTIVE ON THE CENTRAL NERVE SYSTEM CONTAINING THEM | SANOFI S.A. (FR) | 1987-07-22 | — | — | EP | claimed |
| EP-0114770-A2 | Compounds with dinitrogen containing heterocyclic nucleus, their process of preparation and medicines active on the central nerve system containing them | SANOFI S.A. (FR) | 1984-08-01 | — | — | EP | claimed |
| US-11820753-B2 | Inhibitors of bacterial pasta kinases | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2023-11-21 | — | — | US | disclosed |
| US-20230135635-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | Sanford Burnham Prebys Medical Discovery Institute | 2023-05-04 | — | — | US | disclosed |
| US-20230060122-A9 | INHIBITORS OF BACTERIAL PASTA KINASES | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2023-02-23 | — | — | US | disclosed |
| CN-115515589-A | ULK1/2 inhibitors and methods of use thereof | 萨克生物研究学院 | 2022-12-23 | — | — | CN | disclosed |
| EP-4103182-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | Salk Institute for Biological Studies (US) | 2022-12-21 | — | — | EP | disclosed |
| WO-2021163629-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2021-08-19 | — | — | WO | disclosed |
| CN-1926132-B | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMA CO LTD | 2010-12-29 | — | — | CN | disclosed |
| US-20090048282-A1 | PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2008-11-20 | — | — | US | disclosed |
| CN-100355750-C | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMA (US) | 2007-12-19 | — | — | CN | disclosed |
| CN-1926132-A | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMA (US) | 2007-03-07 | — | — | CN | disclosed |
| CN-1473161-A | Pyrazole compounds as protein kinase inhibitors | ��̩��˹ҩ��ɷ�����˾ | 2004-02-04 | — | — | CN | disclosed |
| CN-1469874-A | Pyrazole compounds useful as protein kinase inhibitors | ��̩��˹ҩ��ɷ�����˾ | 2004-01-21 | — | — | CN | disclosed |
| CN-1469875-A | Pyrazole compounds useful as protein kinase inhibitors | ��̩��˹ҩ��ɷ�����˾ | 2004-01-21 | — | — | CN | disclosed |
| US-5795905-A | 3-AMINO-5-PHENYL-1,2,4-TRIAZOLES | NEUROCRINE BIOSCIENCES, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| EP-0846108-A1 | AMINO-SUBSTITUTED THIADIAZOLES, PYRIMIDINES, TRIAZINES OR TRIAZOLES USEFUL AS CTF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1996039400-A1 | AMINO-SUBSTITUTED THIADIAZOLES, PYRIMIDINES, TRIAZINES OR TRIAZOLES USEFUL AS CTF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 1996-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11820753-B2 | Inhibitors of bacterial pasta kinases | SBK3, MAP3K3, MAP4K3 | KCNH2 2861/4885TDP1 2946/4885L3MBTL1 2648/4885 |
| US-20230135635-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | ULK2, ULK1, ULK3 | KCNH2 4862/4885TDP1 607/4885L3MBTL1 2025/4885 |
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT3A, CTNNB1, WNT1 | KCNH2 4701/4885TDP1 2097/4885L3MBTL1 1642/4885 |
| US-20090048282-A1 | PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT1, CTNNB1, WNT3A | KCNH2 4711/4885TDP1 2824/4885L3MBTL1 3260/4885 |
| US-20230060122-A9 | INHIBITORS OF BACTERIAL PASTA KINASES | SBK3, MAP3K3, MAP4K3 | KCNH2 2861/4885TDP1 2946/4885L3MBTL1 2648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.