Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241049 | 0.97 | TSHR (0.46) | TSHRGAAALDH1A1MAPTHPGD | |
| SCHEMBL13521728 | 0.94 | ALOX15 (0.42) | TSHRGAAALDH1A1ALOX15MEN1 | |
| SCHEMBL3241489 | 0.93 | TSHR (0.46) | TSHRGAAALDH1A1MAPTHPGD | |
| SCHEMBL3252753 | 0.92 | TSHR (0.44) | TSHRGAAALDH1A1MAPTHPGD | |
| SCHEMBL3254471 | 0.90 | TSHR (0.46) | TSHRGAAALDH1A1MAPTHPGD | |
| SCHEMBL3127648 | 0.90 | GAA (0.43) | TSHRGAAALDH1A1MAPTHPGD | |
| SCHEMBL3251960 | 0.90 | TSHR (0.43) | TSHRGAAALDH1A1MAPTHPGD | |
| SCHEMBL13521713 | 0.90 | TSHR (0.44) | TSHRGAAALDH1A1MAPTHPGD | |
| SCHEMBL3244932 | 0.89 | TSHR (0.43) | TSHRGAAALDH1A1MAPTHPGD | |
| SCHEMBL13521711 | 0.88 | TSHR (0.44) | TSHRGAAALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | claimed |