Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.55 |
| ▸ | POLB | P06746 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254872 | 0.88 | TDP1 (0.51) | TDP1POLBMAPTLMNAL3MBTL1 | |
| SCHEMBL3252252 | 0.88 | KMT2A (0.51) | TDP1POLBMAPTLMNAALDH1A1 | |
| SCHEMBL3248992 | 0.88 | POLB (0.46) | TDP1POLBMAPTLMNAL3MBTL1 | |
| SCHEMBL3244943 | 0.87 | POLB (0.50) | TDP1POLBMAPTLMNAL3MBTL1 | |
| SCHEMBL3254470 | 0.87 | PKM (0.53) | TDP1POLBMAPTTP53PKM | |
| SCHEMBL4166095 | 0.84 | TDP1 (0.51) | TDP1POLBMAPTLMNAL3MBTL1 | |
| SCHEMBL3251084 | 0.84 | MAPT (0.50) | TDP1POLBMAPTLMNATP53 | |
| SCHEMBL3248556 | 0.84 | MAPT (0.50) | TDP1POLBMAPTLMNAL3MBTL1 | |
| SCHEMBL3252130 | 0.84 | TAS2R14 (0.50) | TDP1POLBMAPTL3MBTL1TP53 | |
| SCHEMBL3250099 | 0.81 | POLB (0.47) | TDP1POLBMAPTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |