Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 1/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.53 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.53 |
| ▸ | RIOK2 | Q9BVS4 | 12/20 | 0.48 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254800 | 0.88 | RIOK2 (0.46) | PRKAG1PRKAA1PRKAB1RIOK2LOXL2 | |
| SCHEMBL3250069 | 0.84 | GRIK1 (0.42) | PRKAG1PRKAA1PRKAB1RIOK2TLR8 | |
| SCHEMBL3249118 | 0.84 | KDM4E (0.51) | PRKAG1PRKAA1PRKAB1NR4A2 | |
| SCHEMBL4162119 | 0.84 | RIOK2 (0.45) | PRKAG1PRKAA1PRKAB1RIOK2PADI4 | |
| SCHEMBL3250859 | 0.80 | RIOK2 (0.45) | PRKAG1PRKAA1PRKAB1RIOK2PADI4 | |
| SCHEMBL3249304 | 0.80 | NR4A2 (0.48) | PRKAG1PRKAA1PRKAB1NR4A2 | |
| SCHEMBL3241765 | 0.80 | NR4A2 (0.53) | MKNK1MKNK2NR4A2 | |
| SCHEMBL3250737 | 0.78 | CYP1A2 (0.41) | PRKAG1PRKAA1PRKAB1NR4A2 | |
| SCHEMBL3242991 | 0.78 | CYP1A2 (0.39) | PRKAG1PRKAA1PRKAB1NR4A2 | |
| Propionic Acid SCHEMBL4162124 | 0.77 | RIOK2 (0.50) | PRKAG1PRKAA1PRKAB1RIOK2PADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |