Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIOK2 | Q9BVS4 | 9/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.37 |
| ▸ | GABRE | P78334 | 2/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246162 | 0.88 | TLR8 (0.37) | RIOK2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL3249865 | 0.86 | KDM4E (0.40) | PRKAG1PRKAA1PRKAB1GABRA1GABRG2 | |
| SCHEMBL3254800 | 0.85 | RIOK2 (0.46) | RIOK2LOXL2PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL3250544 | 0.85 | MMP2 (0.48) | — | |
| SCHEMBL3252380 | 0.84 | CSF1R (0.43) | GABRA1GABRA3GABRB1GABRB2 | |
| SCHEMBL3253850 | 0.83 | SCN9A (0.38) | GABRA1GABRA3GABRB1GABRB2 | |
| SCHEMBL3244562 | 0.81 | CCNC (0.38) | MAP3K11 | |
| SCHEMBL3252050 | 0.81 | GAA (0.40) | — | |
| SCHEMBL3250692 | 0.81 | HPGD (0.34) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3248921 | 0.81 | ALDH1A1 (0.41) | GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |