Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249304 | 0.87 | NR4A2 (0.48) | KDM4ETDP1PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL3250598 | 0.86 | JAK2 (0.50) | KDM4EALDH1A1GAAL3MBTL1GSK3A | |
| SCHEMBL3250737 | 0.85 | CYP1A2 (0.41) | KDM4EPRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL3248589 | 0.84 | PRKAG1 (0.53) | PRKAG1PRKAA1PRKAB1NR4A2 | |
| SCHEMBL3244469 | 0.83 | KDM4E (0.52) | KDM4EALDH1A1GAAPOLBTDP1 | |
| SCHEMBL3248872 | 0.83 | WEE1 (0.41) | KDM4EGAANR4A2CYP1A2HSD17B10 | |
| SCHEMBL4167717 | 0.82 | PDGFRB (0.49) | KDM4EALDH1A1GAAPOLBTDP1 | |
| SCHEMBL3247723 | 0.82 | FASN (0.42) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL3255249 | 0.81 | BRD4 (0.60) | KDM4EALDH1A1GAAPOLBSMN1; SMN2 | |
| SCHEMBL3249048 | 0.81 | POLB (0.54) | KDM4EALDH1A1GAAPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | claimed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |