Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13678746 | 0.87 | EGFR (0.46) | MAPK9EGFRERBB2METFGFR1 | |
| SCHEMBL13304836 | 0.86 | MAPK9 (0.53) | MAPK9EGFRERBB2METFGFR1 | |
| SCHEMBL3257071 | 0.83 | MAPK9 (0.64) | MAPK9EGFRERBB2METFGFR1 | |
| SCHEMBL13304488 | 0.82 | MAPK9 (0.57) | MAPK9EGFRERBB2METFGFR1 | |
| SCHEMBL13304486 | 0.82 | FGFR1 (0.51) | MAPK9EGFRERBB2METFGFR1 | |
| SCHEMBL13678735 | 0.82 | MERTK (0.47) | MAPK9EGFRERBB2METFGFR1 | |
| SCHEMBL13678729 | 0.81 | MAPK9 (0.49) | MAPK9EGFRERBB2METFGFR1 | |
| SCHEMBL13678734 | 0.80 | LRRK2 (0.49) | MAPK9EGFRERBB2METFGFR1 | |
| SCHEMBL13678727 | 0.80 | MAPK9 (0.50) | MAPK9EGFRERBB2METFGFR1 | |
| SCHEMBL3252571 | 0.80 | MAPK9 (0.76) | MAPK9EGFRERBB2METFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833477-B1 | PYRAZOLO-HETEROARYL COMPOUNDS USEFUL TO TREAT TNF-ALPHA AND IL-1 MEDIATED DISEASES | NOVARTIS AG (CH) | 2010-06-02 | — | — | EP | claimed |
| EP-1833477-B1 | PYRAZOLO-HETEROARYL COMPOUNDS USEFUL TO TREAT TNF-ALPHA AND IL-1 MEDIATED DISEASES | NOVARTIS AG (CH) | 2010-06-02 | — | — | EP | disclosed |
| US-20090258874-A1 | PYRAZOLO-HETEROARYL COMPOUNDS | NOVARTIS AG (CH) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258874-A1 | PYRAZOLO-HETEROARYL COMPOUNDS | IL1R1, IL1A, IL1B | MAPK9 2483/4885EGFR 3420/4885ERBB2 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.