Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.58 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.54 |
| ▸ | FOS | P01100 | 1/20 | 0.53 |
| ▸ | JUN | P05412 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | FABP1 | P07148 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16108766 | 0.87 | NR1H4 (0.60) | NR1H4KAT6AFOSJUNKMT2A | |
| SCHEMBL931583 | 0.85 | NR1H4 (0.75) | NR1H4KAT6AFOSJUNKMT2A | |
| SCHEMBL1436279 | 0.85 | NR1H4 (0.63) | NR1H4KAT6AFOSJUNKMT2A | |
| SCHEMBL7260601 | 0.84 | PARP1 (0.60) | NR1H4KAT6AFOSJUNKMT2A | |
| SCHEMBL26049008 | 0.83 | NR1H4 (0.60) | NR1H4KAT6AFOSJUNKMT2A | |
| SCHEMBL16954827 | 0.81 | NR1H4 (0.55) | NR1H4KAT6AFOSJUNKMT2A | |
| SCHEMBL364241 | 0.81 | HPGD (0.56) | NR1H4KAT6AKMT2AMEN1ALDH1A1 | |
| SCHEMBL11739719 | 0.81 | NR1H4 (0.55) | NR1H4KAT6AFOSJUNKMT2A | |
| SCHEMBL8780297 | 0.81 | NR1H4 (0.55) | NR1H4KAT6AFOSJUNKMT2A | |
| SCHEMBL930302 | 0.80 | NR1H4 (0.54) | NR1H4KAT6AFOSJUNKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056195-A1 | NEW COMPOUNDS 575 | ASTRAZENECA AB (SE) | 2010-05-20 | — | — | WO | disclosed |
| US-20100125087-A1 | NEW COMPOUNDS 575 | ASTRAZENECA AB (SE) | 2010-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125087-A1 | NEW COMPOUNDS 575 | PSEN1, PSEN2, BACE1 | NR1H4 2942/4885KAT6A 3313/4885FOS 2374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.